Abstract MicroRNA-34 (miR-34) has been reported to be dysregulated in various human cancers and regarded as a tumor suppressive microRNA because of its synergistic effect with the well-known tumor suppressor p53.Along with the application of MRX34, the first tumor-targeted microRNA drug which based on wella color touch 77 45 miR-34a mimics, on phase I clinical trial (NCT01829971), the significance of miR-34 is increasingly recognized.miR-34 plays a crucial role on repressing tumor progression by involving in epithelial-mesenchymal transition (EMT) via EMT- transcription factors, p53 and some important signal pathways.Not only that, numerous preclinical researches revealed the giant potential of miR-34a on grandpas best cancer therapy through diversiform nano-scaled delivery systems.
Here, we provide an overview about the function of miR-34 in various cancers and the mechanism of miR-34 in tumor-associated EMT.Furthermore, its potential role as a microRNA therapeutic candidate is also discussed.Notwithstanding some obstacles existed, the extensive application prospect of miR-34 on oncotherapy cannot be neglected.